Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.

Controls and treatment protocol Within one experimental setup, statistically calculated to reach highly significant results, we treated and analyzed the following groups (n = 9–14) of mice: Non-allergic: non-sensitized mice, exposed to OVA-aerosol only.

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Results AIT combined with short-term TOFA administration was significantly more effective in suppressing total cell and eosinophil infiltration into the lung, local cytokine production including IL-1β and CXCL1 and showed a trend for the reduction of IL-4, IL-13, TNF-α and IL-6 compared to AIT alone.

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