Substrate Deprivation Therapy to Reduce Glycosaminoglycan Synthesis Improves Aspects of Neurological and Skeletal Pathology in MPS I Mice.

MPS I untreated mice had a reduction in time spent on the inverted grid compared to normal mice at 6 months of age ( Figure 4 A, p < 0.05), MPS I treated mice had improved latency compared to MPS I untreated mice, however this did not reach statistical significance ( Figure 4 A, p > 0.05). 3.3.2.

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