Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.

PLoS Genet · 2017 · PMC5456408 · PMID 28545128

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hedged sentences

0.0000

closest p · 0.0× alpha

0.1700

boldest claim

The sentences

highly significantP = 1.21x10 -11actually significant

Meta-analysis using the inverse-variance method within METAL[ 29 ] resulted in a highly significant associations with neuroblastoma ( Table 1 ; rs6441201: P = 1.21x10 -11 , Odds Ratio 1.23, 95% CI:1.16–1.31 and rs3796727: P = 126x10 -12 , Odds Ratio 1.30, 95% CI:1.21–1.40; rs3796725: P = 2.08 x 10 −11 , Odds Ratio 1.29, 95% CI:1.19–1.38). rs3796727 genotype correlates with methylation status of C

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did not reach statistical significancep = 0.17not close (p > 0.1)

Expression of CPZ is higher in ovarian tissue homozygous for the rs3796727 neuroblastoma-associated risk allele at 4p16, though this did not reach statistical significance (p = 0.17).

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