Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve.

Nat Commun · 2017 · PMC5458508 · PMID 28541271

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nominally significantno p-value reported

In an additive genetic model, we did not find evidence for association between the noncoding rs6601627 and ToF (MAF=0.03, OR=0.89, 95% confidence interval (CI) 0.67–1.20, P =0.46); however, for GATA4 p.Ser377Gly, the association was nominally significant (MAF=0.11, OR=1.24, 95% CI 1.06–1.45.

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