Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice.

Sci Rep · 2017 · PMC5460172 · PMID 28588307

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We also observed a ~74% reduction in the area of osteoid surface to bone surface (OS/BS) in unloaded mice treated with vehicle compared to control mice (p < 0.05), whereas in unloaded mice treated with r-Irisin a strong trend toward increased OS/BS was observed, albeit it was still lower than in control mice (p > 0.05).

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