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The adaptation of <i>Escherichia coli</i> cells grown in simulated microgravity for an extended period is both phenotypic and genomic.

NPJ Microgravity · 2017 · PMC5460176 · PMID 28649637

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showed a trendno p-value reported
A linear fit for the ratios (data sets) of 1000G strain grown under shake flask conditions for 10, 20, or 30 generations (competed with the unadapted lac minus strain) showed a trend consistent with our observations (Supplementary Fig. 3a ).

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