Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers.

At 4 °C, N-OXPHOS capacity showed a trend to decline during the experiment particularly with PM, and no stimulation could be observed with cytochrome c .

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In human skeletal muscle, however, the limitation by the phosphorylation system is highly significant, j ExP (NS) = 0.05 to 0.2 7 , 68 and j ExP (N) = 0.2 with glutamate&malate as substrates 69 , and is even more pronounced in the human heart, with j ExP (N) increasing from 0.52 in healthy controls to 0.59 in heart failure 2 .

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