WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility.

J Cell Biol · 2017 · PMC5461030 · PMID 28473602

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a clear trendno p-value reported

In this study, we focus on a widely dispersed migration mode characterized by dynamic actin-filled pseudopods that we call “α-motility.” Mining genomic data reveals a clear trend: only organisms with both WASP and SCAR/WAVE—activators of branched actin assembly—make actin-filled pseudopods.

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