In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17<i>β</i>-dihydroexemestane.

Pharmacol Res Perspect · 2017 · PMC5464343 · PMID 28603633

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did not reach statistical significanceno p-value reported

It is interesting to note that recombinant CYP2D7*17 protein yielded a 61% decrease in EXE affinity relative to wild type although this observation did not reach statistical significance.

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