Noninvasive tongue stimulation combined with intensive cognitive and physical rehabilitation induces neuroplastic changes in patients with multiple sclerosis: A multimodal neuroimaging study.

Mult Scler J Exp Transl Clin · 2017 · PMC5466147 · PMID 28607750

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closest p · 1.2× alpha

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a trend toward significancep = 0.06so close (0.05 < p ≤ 0.1)

Consistent with our hypothesis, post-CN-NINM training fMRI shows significant increases in BOLD signal in the left DLPFC ( t = 3.55, p = 0.01), dACC ( t = 3.057, p = 0.02) and a trend toward significance in the right DLPFC ( t = 2.3, p = 0.06).

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did not reach statistical significancep < 0.06so close (0.05 < p ≤ 0.1)

T tests comparing the week 14 score to the pre-score reveals that the improvement for the active group is significant ( p < 0.001), whereas the sham group difference did not reach statistical significance ( p < 0.06).

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