Interestingly, histological scoring of the cartilage lesion showed a trend toward increased damage in IL-1 deficient mice, although this increase did not reach significancy.
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Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis.
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