Is plasma caveolin-1 level a prognostic biomarker in metastatic pancreatic cancer?

Cav-1 depletion has been shown to increase chemosensitivity via the intrinsic pathway of apoptosis in MPC.[ 13 , 37 ] Cav-1 has been reported to be upregulated with chemotherapy in pancreatic cancer cells, leading to decreased chemosensitivity.[ 50 , 51 , 52 ] We indicated that patients with higher plasma Cav-1 levels (group 1a) showed a trend toward worse response rates with cisplatin plus gemcitabine ( P = 0.086).

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In the present study, we demonstrated that high plasma Cav-1 levels were significantly associated with a poor prognosis of patients with MPC and that a cisplatin plus gemcitabine chemotherapy regimen showed a decreasing trend in response rates.

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