The extent of the advantage of extra-fine particle ICS over fine-particle ICS may have been overestimated in the unmatched analysis as the matched pairs only showed a trend for a lower risk of pneumonia with extra-fine particle ICS after adjusting for the diagnosis of COPD.
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Risk of pneumonia in obstructive lung disease: A real-life study comparing extra-fine and fine-particle inhaled corticosteroids.
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