Male Seminal Relaxin Contributes to Induction of the Post-mating Cytokine Response in the Female Mouse Uterus.

Although, the large differences between relaxin stimulation and vehicle, both for mRNA and peptide expression in this experiment, failed to reach significance due to apparent non-responder mice, the significant correlation ( p < 0.001) between peptide and mRNA expression strongly implies that the variance in this model is not of a technical nature, but is due to the biological variability in mouse responsiveness.

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Whilst for most products individual variation was too high to yield statistical significance, for both CSF3 and CXCL10, there was a significant ( p < 0.05 ) reduction upon mating with Rln −/− males, reflecting that seen at the mRNA level, as also a strong trend to reduction for CXCL1 ( p = 0.08).

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