Depletion of p21-activated kinase 1 up-regulates the immune system of APC^∆14/+ mice and inhibits intestinal tumorigenesis.

However differences in the blood white cell and lymphocyte counts between PAK1 KO APC ∆14/+ mice and PAK1 WT APC ∆14/+ mice did not reach statistical significance (Fig. 2d ).

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