Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension.

When frequencies of the individual gene variants in the hypertensive patients were compared to those in the two other groups (normotensive males and blood donors) combined, the βENaC i12-17CT variant was found to occur significantly more often among the hypertensive patients than in other groups (p = 0.001) whereas the differences in the prevalences of βENaC G589S (p = 0.15) and γENaC V546I (p = 0.14) did not reach statistical significance.

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