Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice.

Exposure to a Diet Enriched with Fat and Cholesterol Results in the Deficient Hippocampus-Dependent Performance in the Fear Conditioning and Pellet Displacement Tests In the fear conditioning test, in comparison to that in control mice, the number of “good learners” defined by the percentage of time spent with freezing ≥ 50% at the memory recall session was significantly diminished in the dietary-challenged group ( p = 0.017, Fisher's exact test, Figure 5(a) ); also, there was a strong trend to a decreased duration of freezing in this group ( t = 1.96, p = 0.059, t -test, Figure 5(b) ), suggesting reduced contextual memory in mice housed on the high-cholesterol and fat-containing diet.

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