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Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection.

BMC Infect Dis · 2017 · PMC5481962 · PMID 28645263

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Lacking power due to limited number of participants and high variance in TMAO concentrations, might also explain why the elevation of TMAO in treated compared to untreated individuals did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.