Methylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre study.

Br J Cancer · 2017 · PMC5482730 · PMID 28350786

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantP =4.33e −7actually significant

Figure 3 shows a highly significant association (log-rank P =4.33e −7 , Cox P =0.0040, HR 0.67, 95% CI 0.51, 0.88) between OS and methylation of MYLK3 , most prominently in totally debulked patients.

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borderline significantP =0.053so close (0.05 < p ≤ 0.1)

Higher methylation of the MYLK3 locus is associated with OS in patients with the least RD in all three independent cohorts of patients ( Figure 2D and E ), however the TOC-Charité data set was borderline significant ( P =0.053).

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did not quite reach significanceP =0.06so close (0.05 < p ≤ 0.1)

a clear trendno p-value reported

Although MYLK3 did not quite reach significance ( P =0.06), in the TCGA analysis there is a clear trend in the survival curves ( Figure 2A–C ) towards improved survival with increased methylation of MYLK3 in all data sets.

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