Time since menopause and skeletal muscle estrogen receptors, PGC-1α, and AMPK.

There was a nonsignificant trend for the ratio of ERα nuclear/cytosolic protein to increase after E 2 treatment in both groups (treatment main effect, P = 0.072), and this ratio tended to be lower in LPM compared with EPM women (group main effect, P = 0.069; Fig. 2 E).

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Although our previous study 5 reported a significant group–by-treatment interaction ( P < 0.05) for GDR, such that E 2 increased GDR in EPM women, but decreased GDR in LPM women, in this smaller subset, the interaction (interaction, P = 0.14) did not reach statistical significance (Table 1 ).

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