α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca<sup>2+</sup> homeostasis and mitochondrial ATP production.

b Increased mitochondrial circularity in EGFP-α-synuclein and EGFP-α-synucleinA53T cells, EGFP-α-synucleinA30P cells also showed a trend for increased circularity but this did not reach significance; N = 30. c Decreased mitochondrial cytosolic distribution (increased mitochondrial clustering) in EGFP-α-synuclein, EGFP-α-synucleinA53T and EGFP-α-synucleinA30P cells; N = 30. d , e , f No changes in ER cytosolic distributions, numbers of branch points or branch lengths in EGFP-α-synuclein, EGFP-α-synucleinA53T or EGFP-α-synucleinA30P cells; N = 10.

also in 53,322 other papers