ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population.

Cell Mol Life Sci · 2017 · PMC5487885 · PMID 28220208

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did not reach statistical significanceno p-value reported

3 c); however, this did not reach statistical significance when multiple fields were analysed (Fig. 3 d).

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