Analyzing green and red zones in a case-by-case study (i.e., comparing Ki67 for red and green zones within the same case), the obtained results varied depending on the case: IR cases presented either statistical significance ( p < 0.05, C1022) ( Figure 8 ) or a trend towards significance (0.15 > p > 0.05, 1026, C971), whereas HR cases did not present statistical significance.
Ki67 analysis: Comparison of responding and non-responding zones : green and red areas of the nosological images, disregarding the case categorization, showed a trend, with green zones having lower Ki67 values (42.9 ± 32.6%, n = 50 fields) than red zones (52.9 ± 25.1%, n = 121 fields) (see Figure 7 ).
Regarding them, in figure S8B an increasing trend in the percentage of acellular space is observed: control cases presented only 19.1 ± 6.9%, whereas ascending values were observed in treated cases: LR cases with 27.5 ± 8.2%, IR cases with 37.4 ± 11.0% and HR cases 44 ± 15.3% which is almost half of the field.