No significant difference was apparent between potassium oxprenoate and spironolactone in all three studies with respect to the urinary Na + /K + ratio demonstrating that RU 28318 has an antimineralocorticoid effect identical to that produced by the same molar dose of spironolactone.
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30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development.
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