Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis.

Compared with the K14CreERβ F/F p53 F/F mice, the median mammary tumor-free survival period of K14CreERβ F/+ p53 F/F mice was noticeably shorter than that of K14Crep53 F/F animals; however, the difference did not reach statistical significance, indicating that loss of both ERβ alleles might be necessary to enhance tumorigenesis in these mice (Fig 2c, d ; P = 0.06).

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