Fusion of a superfamily 1 helicase and an inactivated DNA polymerase is a signature of common evolutionary history of Polintons, polinton-like viruses, Tlr1 transposons and transpovirons.

Thus, it appears that PLVs and Tlr1 elements are parasitized by smaller insertion elements and that GIY-YIG and HNH homing endonuclease domains were independently appended to the helicases of Tlr1 and PLVs, respectively. Strikingly, the HHpred searches seeded with the sequences of transpoviron Lentille and PLV-SAF5 returned moderately significant matches (HHpred Probabilities of 90 and 83, respectively) to protein-primed family B DNA polymerases (pDNAP) ( Supplementary Figure S5 ).

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