Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy.

Interestingly, analysis of the TB + HRZ group data using the principle coordinates from the weighted UniFrac analysis showed a significant trend only up to W12 (Fig. 4a , trend line not shown, R 2 = 0.9095, p = 0.0463 based on regression analysis up to W12).

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As might be predicted, the bacterial composition of the stool samples from the TB + HRZ mice showed highly significant differences in comparison to that of the mice from naïve and TB groups (Fig. 3 , Additional file 3 : Figure S3b).

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