showed a trendP = 0.7401
The Kaplan–Meier analysis showed a trend toward better OS ( P = 0.7401) in patients that experienced neither dose reduction nor dose delay (median OS not reached), followed by patients that experienced only dose delay (median OS not reached), than patients with only dose reduction (median OS = 124 months) and finally patients that experienced both dose reduction and dose delay (median OS = 92 months).