Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study.

showed that regions in 3q, 6p, 11p, 11q, 18q and 19q were significantly altered in breast cancers showing pCR, compared with non–responders, but this did not reach statistical significance when adjusted for multiple testing (FDR = 0.59) [ 41 ].

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This is highly significant as we would expect the main discriminator to be ESR1 between these cohorts.

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