When pAIH and aAIH (aAIH untreated: n = 88; aAIH treated: n = 34) were compared, pAIH had higher IL-2 serum level at diagnosis and aAIH only showed a trend to a decline of IL-2 during therapy ( Fig 3E ).
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Pediatric autoimmune hepatitis shows a disproportionate decline of regulatory T cells in the liver and of IL-2 in the blood of patients undergoing therapy.
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