Intraoperative frozen section can be reduced in thyroid nodules classified as Bethesda categories V and VI.

These cytological diagnoses are determined, as follows: 1) Bethesda I, nondiagnostic or unsatisfactory, 2) Bethesda II, benign, 3) Bethesda III, atypical of indeterminate significance or follicular lesion of indeterminate significance, 4) Bethesda IV, follicular neoplasm or suspicious for a follicular neoplasm, 5) Bethesda V, suspicious for malignancy, and 6) Bethesda VI, malignant.

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