In vitro model to study the effects of matrix stiffening on Ca²⁺ handling and myofilament function in isolated adult rat cardiomyocytes.

Although the maximal generated force ( F max ) and maximal rate of force redevelopment (K tr ) tended to increase in response to matrix stiffening ( P = 0.24 and 0.09 respectively) this failed to reach statistical significance (Fig. 6 ).

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