Donor LT-HSCs from infected mice showed a trend towards poorer reconstitution in BM (2.72 x 10 7 ± 1.41 x 10 7 cells vs. 6.96 x 10 6 ± 7.89 x 10 6 cells, naive vs. infected mice), and the same was observed in the spleen ( Fig 2G ).
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TNF signalling drives expansion of bone marrow CD4+ T cells responsible for HSC exhaustion in experimental visceral leishmaniasis.
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