Pharmacodynamic Monitoring of RO5459072, a Small Molecule Inhibitor of Cathepsin S.

Front Immunol · 2017 · PMC5512459 · PMID 28769925

Europe PMC DOI

hedged sentences

0.0005

closest p · 0.0× alpha

0.0005

boldest claim

The sentences

highly significantp = 0.0005actually significant

Effect of drug on peak Lip10 stain index comparing the results from subjects receiving placebo versus subjects receiving 100 mg was highly significant ( p = 0.0005, Kruskal–Wallis).

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a clear trendno p-value reported

Although a clear trend is shown that high Lip10 accumulation correlated with a strong decrease in MHCII surface expression levels, the low r 2 value of 0.35 indicates that Lip10 accumulation alone is a relatively poor predictor of MHCII expression decrease.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.