Apixaban Enhances Vasodilatation Mediated by Protease-Activated Receptor 2 in Isolated Rat Arteries.

Pre-incubation of intact arteries with APX enhanced vasodilation to SLIGRL, either in the presence or in the absence of L -NNA, though this effect did not reach statistical significance in BA (MRA, P < 0.01, MRA with L -NNA, P < 0.01; BA, P = 0.108, BA with L -NNA P < 0.01; Table 2 ); APX was ineffective in endothelium-denuded MRA, where SLIGRL did not induce significant vasodilatation.

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