Yeast longevity promoted by reversing aging-associated decline in heavy isotope content.

10 , 11 In contrast, 17 metabolites with an increasing trend were found in both strains and showed no enrichment for any metabolic pathways ( Supplementary Table S2 ).

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A total of 2,936 high-confidence metabolites exhibited distinctive clustering with respect to each time point for both strains(R2Y>0.98, Q2> 0.95), indicating a clear trend in age-associated metabolome changes ( Figure 1a,b ).

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Of 237 metabolites with a KEGG entry, 58 metabolites that showed a decreasing trend with time were shared in both strains, and over-represents a few metabolic pathways, including arginine and proline metabolism (urea cycle) and oxidative phosphorylation ( Supplementary Table S2 ), two processes for energy generation and waste disposal in catabolism that also decline in aging. 10 , 11 In contrast, 17 metabolites with an increasing trend were found in both strains and showed no enrichment for any metabolic pathways ( Supplementary Table S2 ).

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