X-Ray Phase Contrast Tomography Reveals Early Vascular Alterations and Neuronal Loss in a Multiple Sclerosis Model.

It is highly significant that the reduced contrast of the vessels is less intense in MSC-treated mice; in this context, we have seen in immunohistochemistry studies that the BBB is far less compromised in MSC-treated than in untreated EAE mice, with intact tight junctions and fewer leaky vessels (data not shown), suggesting that the vessels are less fragile in MSC-treated EAE mice.

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These representative results show a clear trend towards a decrease in cell numbers as early as one day after disease onset, followed by a dramatic decrease five days after disease onset.

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