In the spleen, mTACI‐Fc, and to a lesser extent mBAFFR‐Fc, reduced antibody‐secreting cell numbers and showed a trend toward reduction of CD138 + cells (Fig. 2 A and B).
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A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells.
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