High-Saturated-Fat Diet Increases Circulating Angiotensin-Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient-Dependent Increases of Blood Pressure.

Genotype‐dependent differences in pulse pressure (PP) values failed to reach statistical significance after adjustment for sex, age, and BMI (AA/AG vs GG, 39±8 mm Hg vs 44±7 mm Hg, P =0.026, P adj =0.081).

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In a linear regression model adjusted for sex, age, and BMI, the association of the ACE rs4343 polymorphism with systolic blood pressure and pulse pressure was highly significant (recessive model: β SBP =0.25 and P SBP =0.002; β PP =0.24 and P PP =0.002).

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