Isosorbide Dinitrate, With or Without Hydralazine, Does Not Reduce Wave Reflections, Left Ventricular Hypertrophy, or Myocardial Fibrosis in Patients With Heart Failure With Preserved Ejection Fraction.

Arterial Hemodynamics Treatment with ISDN did not reduce brachial systolic blood pressure ( P =0.09), yet tended to reduce central systolic blood pressure (visit 2 versus visit 1: −27.6 [95% CI −54.0 to −1.3]; visit 3 versus visit 1: −30.4 [95% CI −58.2 to −2.6] mm Hg; overall P =0.051; Table 2 ), although this reduction did not reach statistical significance.

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