Genetic loci associated with an earlier age at onset in multiplex schizophrenia.

Along with the 185 initial probands with extremely early AAO (n = 94) and extremely late AAO (n = 91), those unrelated schizophrenia patients could be divided into four subgroups (the earliest, earlier, later, and latest AAO) and exhibited an increasing trend of average AAO (Supplementary Figure S2 ).

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When 132 patients with an earlier AAO and 158 patients with a later AAO were included, a significant trend in the 14-SNP GRS was detected among those unrelated probands from 4 family groups with the earliest, earlier, later, and latest AAO.

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