Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis.

Mol Oncol · 2016 · PMC5528958 · PMID 26601720

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a clear trendno p-value reported

When comparing methylation level between smokers and never‐smokers in the TCGA cohort, none of the CpGs identified in the present study were significantly differentially methylated; however, there was a clear trend that these CpGs were hypermethylated in tumors from smokers/former smokers.

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