Interestingly, comparing patients with stage IIIB disease, significant decreases in serum concentrations of Trp ( P =0.018) and increases in IDO activity ( P =0.012) were found in patients with stage IV disease, whereas the Kyn concentration did not reach statistical significance ( Table 4 ).
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The status of immunosuppression in patients with stage IIIB or IV non-small-cell lung cancer correlates with the clinical characteristics and response to chemotherapy.
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