Chemotherapy-induced gastrointestinal toxicity is associated with changes in serum and urine metabolome and fecal microbiota in male Sprague-Dawley rats.

Although hippurate excretion is susceptible to body weight changes and could thus represent a non-specific response to drug toxicities [ 58 ], we observed an interesting trend in hippurate formation.

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The relative abundance of Proteobacteria was also increased in 5-FU and Oxaliplatin groups, but the change from baseline did not reach statistical significance.

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