Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group.

In fact, an ICV reduction in MDD patients who reported having made suicidal plans or attempts was nearly significant at the study-wide level ( P =4.12 × 10 −3 ), with a Cohen’s d =−0.284, or a 2.87% smaller ICV compared to the CTL group.

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