highly significantP = 6.9 × 10 −8
When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model ( P = 6.9 × 10 −8 ).
When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model ( P = 6.9 × 10 −8 ).
Similar to meta-analysis in the three new cohorts, traditional random effects meta-analysis was only nominally significant (β = 0.12, P = 0.02), but highly significant based on the Han/Eskin model ( P = 6.89 × 10 −8 ) ( Table 3 ).