Plasma REST: a novel candidate biomarker of Alzheimer's disease is modified by psychological intervention in an at-risk population.

This is due to a near-significant increase in REST pre-intervention to post intervention for MBSR patients (0.19, s.e.=0.10, P =0.055, REST difference +38.70 pg ml −1 ), which was not present for pre- to post changes in REST for the controls (−0.11, s.e.=0.08, P =0.178, REST difference −8.60 pg ml −1 , Figure 2a ).

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REST and surrogate AD markers Partial correlation analyses, co-varying for APOE genotype, demonstrated associations with hippocampal volume, entorhinal cortex volume, whole brain volume and a trend toward significance for ventricular volume ( Table 2 ).

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