Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews.

The overall results were inconclusive regarding the impact of AIT on lung function when compared to placebo: SMD for PEF 0.14 (95% CI −0.33 to 0.61) and SMD for FEV1 −0.32 (95% CI −0.96 to 0.31).with high between study heterogeneity (I 2 = 81% for PEF; and I 2 = 61% for FEV1) In seven studies reporting on lung function deterioration (simply as improved, worsened or the same), there was an overall trend implying lung function improvement after immunotherapy, but this did not reach statistical significance (RR 0.89; 95% CI 0.73–1.10).

also in 4,871 other papers