Temporal and spatial changes of cells positive for stem-like markers in different compartments and stages of human colorectal adenoma-carcinoma sequence.

However, we have found that although the difference did not reach statistical significance, the density grading scores were higher in CRC patients with node involvement than those without (node negative vs. node positive: LGR5, 14.89 ± 1.20 vs. 18.00 ± 2.19; ALDH1, 18.00 ± 1.37 vs. 22.22 ± 2.59; both P < 0.05 by the Mann–Whitney test).

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