GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency.

Although the change in expression levels of IFN- α and IL-22 mRNA in GM-CSF-deficient compared with wild-type mice did not reach statistical significance at days 1 and 3 after IMQPD, the observed numerical variations are consistent with the hypothesis that the early significant increase in pDC skin infiltration at day 1 is accompanied by an intermittent rise in cutaneous IFN- α expression that is followed by an increase in cutaneous IL-22 expression between days 1 and 3, finally reaching statistical significance at day 6.

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